Developing a Natural Version of Triple Anticoagulant Therapy

...as a solution for microclots and for Long Covid recovery

Oct 21, 2023

A couple of months ago, I wrote a Substack piece that asked the question:

“Are there any natural remedies or over-the-counter (OTC) products or ingredients that can help with microclotting and platelet hyperactivation in Long Covid?”

Here’s the link to the article.

In that previous piece, I discussed where I would start that research and the process I would go through to answer that question.

And I stopped there.

For two reasons:

That research process was going to take a ton of time and energy.
I wanted to be very clear on what I was going to say before I shared it on social media channels, because of fears of censorship and pushback by the Medical Establishment and Scientific Community.

I’ve now had the time to do that research.

And while I’m still worried about censorship and blowback, my drive to use this information to help people is stronger than my fear of any repercussions.

So it’s time to share this with the world.

Here today I’m going to recap Triple Anticoagulant Therapy, which was the starting point for this project, and the principles I used to research and design a natural version of the pharmaceutical drug cocktail.

Then over the next four weeks, I’ll be sharing with you the science behind each of the ingredients that are in the natural version of Triple Anticoagulant Therapy that I’ve developed and why I chose them.

At the end you will have the full story of the design and development of this natural version of Triple Anticoagulant Therapy.

I’m currently having that formula manufactured as an over-the-counter (OTC) natural supplement. It will be available in late December 2023 or early January 2024 (more on that later).

So now let’s get started and turn our attention back to Triple Anticoagulant Therapy…

Triple Anticoagulant Therapy - A Recap

Triple Anticoagulant Therapy is a cocktail of three pharmaceutical drugs that inhibit coagulation and clotting - apixaban, clopidogrel, and aspirin. Hence the name “Triple Anticoagulant” therapy.

A fourth drug, pantoprazole, is added to protect the GI tract from the known adverse effects of aspirin, which can cause GI bleeding.

Each drug component of the therapy has a different mechanism of action:

Apixaban is a true anticoagulant that inhibits Factor Xa, an enzyme in the Coagulation Cascade.
Aspirin is a platelet activation inhibitor which targets the COX-1 and COX-2 enzymes.
Clopidogrel is a second platelet activation inhibitor that targets the P2Y1 and P2Y12 G-protein coupled receptors (GPCRs).
Pantoprazole is a proton pump inhibitor that is in the drug cocktail for gastric protection.

Here’s all that in table form:

A pilot clinical study was conducted using Triple Anticoagulant Therapy to treat Long Covid patients. (Ref 1)

Here are the major finding from that study (all from Ref 1):

For each Long Covid symptom evaluated, >74% of patients saw that symptom resolve and no longer be present.
80% of the Long Covid patients (73 of 91 patients) showed enough of an improvement to be considered “recovered” from Long Covid.
Triple Anticoagulant Therapy reduced microclotting and platelet hyperactivation in all of the Long Covid patients judged to be “recovered”.
Triple Anticoagulant Therapy DID NOT reduce microclotting and platelet hyperactivation in the 20% of Long Covid patients that were judged to have “NOT recovered”.

Here’s a roundup of all my past pieces on Triple Anticoagulant Therapy if you want to read more and look over the data again yourself:

At the end of the day, Triple Anticoagulant Therapy is the only treatment I’ve seen in the literature that actually helps Long Covid patients recover and has data to back up the improvements in the pathophysiology of Long Covid.

But many doctors are reluctant to prescribe Triple Anticoagulant Therapy until it’s been evaluated in more clinical studies. I know this because I’ve talked to doctors (they reached out to me) and it’s the story I hear over and over again from Long Covid patients that I talk to.

The fact that Triple Anticoagulant Therapy is effective in Long Covid, coupled with the fact that a lot of people can’t get that therapy, is why I think it’s worth it to make an accessible, widely-available, and natural OTC version of Triple Anticoagulant Therapy.

How do we design a natural version of Triple Anticoagulant Therapy?

Three words: Mechanisms of Action.

As a medicinal chemist, I spend all day, every day thinking about mechanisms of action for drugs, natural products, and other biologically active molecules (chemical probes, drug leads, etc.)

The reason that Triple Anticoagulant Therapy appears to work in Long Covid is because it utilizes three separate mechanisms of action that inhibit coagulation and clotting.

So the real question that we need to be asking is:

Are there any natural remedies or over-the-counter (OTC) products or ingredients that have the same mechanisms of action as the drugs in Triple Anticoagulant Therapy?

If we want to think about that graphically, we can look at it as a table:

So the work I have done is to dive deep into the scientific literature to find natural products or supplement ingredients that are Factor Xa inhibitors, COX-1/2 inhibitors, and P2Y1/12 inhibitors.

I’ll be sharing each of those three stories with you over the next three weeks. Plus one bonus story at the end.

So stay tuned!

For now, if you’re interested in getting a bottle of the natural version of Triple Anticoagulant Therapy as soon as ordering opens, go to www.getLongCovidhelpnow.com and put your name on the notification list.

If you want to hear more about this natural supplement, come join my email list or the Road to Long Covid Recovery Facebook Group.

Leave me a comment below and let me know what you think.

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Reference

Treatment of Long COVID symptoms with triple anticoagulant therapy. Research Square Preprint 2023, rs-2697680/v1. https://doi.org/10.21203/rs.3.rs-2697680/v1

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